Of Italian ancestry, Sophia Bush attended the University of California majoring in Journalism until her junior year. While studying, she was offered a role on One Tree Hill as Brooke Davis which she preferred over finishing college.

Her first major film project was Van Wilder. After the success of the film, Sophia Bush began appearing in a couple of TV shows such as  Sabrina, the Teenage Witch, Punk'd, and Nip/Tuck. Sophia Bush has starred in films like John Tucker Must Die, Stay Alive, and The Narrows. John Tucker Must Dieis a blockbuster film that grossed over $60 million worldwide.