Tyler is famous for her role as Andrea Marino in the first season of Ghost Whisperer. She also voiced for the character Lana Kane in Archer. She also had recurring roles in 24, CSI: Crime Scene Investigation, Talk Soup (1991) and Friends as Charlie Wheeler. She worked with Scott Rockett while performing at The Laugh Factory in Hollywood. While hosting Talk Soup, she also worked with Rocket who produced E! True Hollywood Story (1996) at E! Entertainment Television. She currently works as a co-host in The Talk where she replaced Holly Robinson Peete. She is a regular contributor to Glamour and Jane magazines. She has her own podcast called Girl on Guy with Aisha Tyler where she regularly invites her comedian friends to be her guests.

Aisha Tyler penned a collection of humorous essays titled Swerve: Reckless Observations of a Postmodern Girl (2004). She is an avid gamer and she lent her voice to the 2010 video game Halo: Reach. Tyler has a guest appearance in the single of Kanye West, Slow Jamz, that also featured Twista and Jamie Foxx. She was featured as #61 in Maxim magazine’s list of Hot 100 of 2002 and #72 on Hot 100 of 2005. Right now, she is married to Jeff Tietjens. Her estimated net worth is $8 million.