As of March 2012, Ana Lucia de Mattos Barretto Villela's estimated net worth amounts to $3.6 billion. She actually came from one of the oldest and prominent banking families in Brazil. Her family owns Banco Itau which merged with Unibanco in 2008.

Now, Itau Unibanco Holding SA is Brazil's second biggest bank and Ana Lucia de Mattos Barretto Villela is one of the largest individual shareholders. She currently sits as the President of Alana Institute, a non-profit organization established in 1944 to promote education, social work and culture.