Bob Gale started creating his own comic book in his teenage years. After the completion of his first work, The Green Vomit, Bob Gale co-founded the popular comic book titled St. Louis. He has also written DC Comics' Batman and for Marvel Comics, he wrote the Ant-Man's Big Christmas.

As a screenwriter, Bob Gale has collaborated with other writers for films such as I Wanna Hold Your Hand, Trespass, Used Cars, A Field of Honor, Back to the Future, Amazing Stories, Kolchak: The Night Stalker, and 1941.

Bob Gale is currently working on with the Marvel comic book, Daredevil. In September 2012, Bob Gale is estimated to be worth $15.5 Million.